Advanced skin regeneration with polynucleotide (PDRN) injections, administered by experienced clinicians at our Thurloe St Dental clinic in the heart of South Kensington, London.
Call 020 7584 5551
Book your initial consultation for polynucleotides at our Thurloe Street Dental clinic near South Kensington tube station. Speak to our team to find out if this treatment is right for you.
What Are Polynucleotides
A New Generation of Skin Regeneration
At Thurloe Street Dental & Implant Centre in South Kensington, we are pleased to offer polynucleotide (PDRN) injections — one of the most talked-about advancements in aesthetic medicine.
Polynucleotides are injectable treatments derived from highly purified DNA fragments (polydeoxyribonucleotides, or PDRN). They work by stimulating the skin’s own repair and regenerative processes, encouraging new collagen production, improving hydration, and supporting healthier, more resilient skin over time.
Unlike dermal fillers, polynucleotides do not add volume or change facial structure. Instead, they work with your body’s natural biology to restore and rejuvenate from within, making them suitable for patients seeking subtle, natural-looking improvement in skin quality.
~30 Minutes Per Session
A quick, in-clinic procedure with minimal disruption to your day.
2–3 Initial Sessions
A course of treatments is recommended for optimal results.
6 mo Maintenance Interval
Results can be maintained with periodic top-up treatments.
72 hr Recovery Time
Minimal downtime — most patients resume normal activities quickly.
How It Works
What Happens During Your Treatment
Polynucleotide injections are administered using very fine needles directly into the skin of the treatment area. The PDRN molecules are absorbed by skin cells, where they promote tissue repair, stimulate fibroblast activity, and support the production of collagen and elastin.
Initial Consultation
Your clinician will discuss your skin concerns, assess your suitability, and design a personalised treatment plan. No obligation, no pressure.
Preparation
The treatment area is cleansed, and a topical numbing cream may be applied to ensure your comfort throughout the procedure.
Polynucleotide Injections
Your clinician administers a series of small injections across the target area. The session typically takes around 20–30 minutes.
Aftercare & Follow-Up
You will receive clear aftercare guidance. We recommend a second session approximately three to four weeks later, and may invite you for a review to assess progress.
Who Is It For
Treatment Areas & Suitability
Polynucleotides are particularly well suited to patients who are noticing early signs of skin ageing, loss of skin quality, or areas of concern that they would like to address in a natural, non-volumising way. Treatment areas include:
- Face & periorbital area
- Under-eye hollows
- Neck & décolletage
- Hands
- Scalp (hair concerns)
- Acne scarring
A consultation is required before treatment to ensure polynucleotides are appropriate for you. Polynucleotides are generally not recommended for patients who are pregnant or breastfeeding, those with certain autoimmune conditions, or patients with known sensitivities to the components of the product.
Frequently Asked Questions
Everything You Need to Know
What do polynucleotides do for the skin?
Polynucleotides stimulate the skin’s natural repair mechanisms by activating fibroblast cells, which produce collagen and elastin. Over the course of treatments, patients may notice improvements in skin texture, hydration, firmness, and overall skin quality. They can also help reduce the appearance of fine lines and improve skin tone.
How many sessions of polynucleotides do I need?
For most patients, we recommend an initial course of two to three sessions, spaced approximately three to four weeks apart. To maintain your results, a top-up treatment every six months is generally advisable. Your clinician will tailor the plan to your individual needs during your consultation.
Are polynucleotide injections painful?
Most patients find the treatment well-tolerated. A topical numbing cream can be applied beforehand to minimise any discomfort. You may experience some mild stinging during the injections, but this is brief. Any redness or tenderness at the injection sites usually settles within 24 to 72 hours.
Are there any side effects?
Side effects are generally mild and temporary. These may include redness, minor swelling, or small bumps at the injection sites, which typically resolve within a few days. As with any injectable treatment, there is a small risk of bruising. Your clinician will discuss all potential risks with you at your consultation.
When will I see results from polynucleotides?
Because polynucleotides work by stimulating your body’s own biological processes, improvements develop gradually. Some patients notice a difference in skin quality within a few weeks of their first session; however, the most noticeable results are typically seen after a course of treatments, particularly following the second or third session.
Are polynucleotides the same as Profhilo or dermal fillers?
No. Polynucleotides, Profhilo, and dermal fillers are different treatments with different mechanisms. Profhilo is a hyaluronic acid-based biostimulator that hydrates and stimulates collagen. Dermal fillers add volume and structure. Polynucleotide treatment primarily works through tissue regeneration and focuses on improving skin quality rather than hydration or volume. In some cases, these treatments can be used in combination; your clinician will advise you accordingly.
How much do polynucleotide treatments cost in South Kensington?
We offer a free initial consultation for polynucleotide treatment at our South Kensington clinic. Please call us on 020 7584 5551 or book online for current pricing information. Our team will be happy to discuss your options and provide a personalised treatment plan.
Why Choose Us
Polynucleotides at Thurloe Street
At Thurloe Street Dental & Implant Centre, our facial aesthetic clinicians combine extensive medical and dental training with specialist expertise in non-surgical treatments. We are conveniently located just minutes from South Kensington underground station, and serve patients from across Chelsea, Knightsbridge, Fulham, Mayfair, and the wider London area.
We take a conservative, patient-centred approach to facial aesthetics. Our priority is always to ensure that any treatment we recommend is appropriate for you, with honest advice and realistic expectations discussed at every stage. All the injectable treatments are performed by our qualified, experienced clinicians in a safe, regulated environment.
We also offer a broad range of complementary facial aesthetic treatments, including Profhilo, dermal fillers, anti-wrinkle injections, and PRP therapy — allowing us to design a holistic treatment plan tailored to your individual goals.
Book your initial consultation at our South Kensington dental clinic today. Our friendly team is on hand to answer any questions you may have.
